Judith Klumperman
PI of Research Project 4:
“Unravelling HOPS dependent and independent mechanisms of VPS41 function in neuronal lysosome biogenesis “
CONTACT
Prof. Dr. Judith Klumperman
University Medical Center Utrecht
Department of Cell Biology
Heidelberglaan 100
CX-Utrecht
The Netherlands
phone: + 31 88 755 6550
fax: + 31 88 755 5590
j.klumperman@umcutrecht.nl
website Klumperman Lab
KEY PUBLICATIONS
CORVET, CHEVI and HOPS – multisubunit tethers of the endo-lysosomal system in health and disease. van der Beek J, Jonker C, van der Welle R, Liv N, Klumperman J (2019) J Cell Sci 132:jcs189134.
Single organelle dynamics linked to 3D structure by correlative live-cell – 3D electron microscopy. Fermie J, Liv N, Ten Brink C, van Donselaar EG, Müller WH, Schieber NL, Schwab Y, Gerritsen HC, Klumperman J (2018) Traffic 19:354-69.
Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions. Jonker CTH, Galmes R, Veenendaal T, Ten Brink C, van der Welle REN, Liv N, de Rooij J, Peden AA, van der Sluijs P, Margadant C, Klumperman J. (2018) Nat Commun 9:792.
hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins. Pols M, van Meel E, Oorschot V, ten Brink C, Fukuda M, Swetha MG, Mayor S, Klumperman J (2013) Nat Commun 4:1361.
The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion. Pols MS, ten Brink C, Gosavi P, Oorschot V, Klumperman J (2013) Traffic 14:219-32
Lysosomal protein composition, acidic pH and sterol content are regulated by a Light-dependent pathway in metazoan cells. Swetha MG, Sriram V, Krishnan KS, Oorschot VMJ, ten Brink C, Klumperman J, Mayor S (2011) Traffic 12:1037-55
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function. Saftig P, Klumperman J (2009) Nat Rev Mol Cell Biol 10:623-35
Correlative light-electron microscopy (CLEM) combining live-cell imaging and immunolabeling of ultrathin cryosections. van Rijnsoever C, Oorschot V, Klumperman J (2008) Nat Methods 5:973-80.
Immuno-electron tomography reveals the existence of free COPII-coated transport carriers. Zeuschner D, Geerts WJC, van Donselaar E, Humbel. B, Slot JW, Koster AJ, Klumperman J (2006) Nat Cell Biol 8:377-83
Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins. Peden AA, Oorschot V, Hesser, B, Austin CD, Scheller RH, Klumperman J (2004) J Cell Biol 164:1065-76