Publications

 

2020

[14] Comprehensive Draft of the Mouse Embryonic Fibroblast Lysosomal Proteome by Mass Spectrometry Based Proteomics. Ponnaiyan S, Akter F, Singh J, Winter D (2020) Sci Data 7(1):68. Abstract

[13] Uncoupling Endosomal CLC chloride/proton Exchange Causes Severe Neurodegeneration. Weinert S, Gimber N, Deuschel D, Stuhlmann T, Puchkov D, Farsi Z, Ludwig CF, Novarino G, López-Cayuqueo KI, Planells-Cases R, Jentsch TJ (2020) EMBO J 39(9):e103358. Abstract

[12] The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons. Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D’Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, Knöll B, Capell A, Damme M (2020) Cell Rep 30:3506-3519.e6. Abstract

[11] Systematic Comparison of Strategies for the Enrichment of Lysosomes by Data Independent Acquisition. Singh J, Kaade E, Muntel J, Bruderer R, Reiter L, Thelen M, Winter D (2020) J Proteome Res 19(1):371-81. Abstract

2019

[10] VPS41 recessive mutation causes ataxia and dystonia with retinal dystrophy and mental retardation by inhibiting HOPS function and mTORC1 signaling. van der Welle REN, Jobling R, Burns C, Sanza P, ten Brink C, Fasano A, Chen L, Zwartkruis FJ, Zwakenberg S, Griffin EF, van der Beek J, Veenendaal T, Liv N, Blaser S, Sepulveda C, Lozano AM, Yoon G, Asensio CS, Caldwell GA, Caldwell KA, Chitayat D, Klumperman J (2019) bioRxiv 2019; doi:10.1101/2019.12.18.867333.

[9] Lysosomal Integral Membrane protein-2 (LIMP-2/SCARB2) Is Involved in Lysosomal Cholesterol Export. Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S, Ikonen E, Saftig P, Neculai D. (2019) Nat Commun 10(1):3521 Abstract

[8] ER-phagy and human diseases. (Review) Hübner CA, Dikic I (2019) Cell Death Differ doi: 10.1038/s41418-019-0444-0. Abstract

[7] A Mathematical Model of Lysosomal Ion Homeostasis Points to Differential Effects of Cl Transport in Ca2+ Dynamics. Astaburuaga R, Quintanar Haro OD, Stauber T*, Relógio A* (2019) Cells 8(10). pii: E1263. Abstract (*These authors contributed equally to the work)

[6] Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking. Schmidtke C, Tiede S, Thelen M, Käkelä R, Jabs S, Makrypidi G, Sylvester M, Schweizer M, Braren I, Brocke-Ahmadinejad N, Cotman SL, Schulz A, Gieselmann V, Braulke T (2019) J Biol Chem pii: jbc.RA119.008852. Abstract

[5] A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five. Khundadze M, Ribaudo F, Hussain A, Rosentreter J, Nietzsche S, Thelen M, Winter D, Hoffmann B, Afzal MA, Hermann T, de Heus C, Piskor EM, Kosan C, Franzka P, von Kleist L, Stauber T, Klumperman J, Damme M, Proikas-Cezanne T, Hübner CA (2019) Neurobiol Dis 127:419-431. Abstract

[4] ATG-18 and EPG-6 are Both Required for Autophagy but Differentially Contribute to Lifespan Control in Caenorhabditis elegans. Takacs Z, Sporbeck K, Stoeckle J, Prado Carvajal MJ, Grimmel M, Proikas-Cezanne T (2019) Cells 8(3). pii: E236. Abstract

[3] Automated Detection of Autophagy Response Using Single Cell-Based Microscopy Assays. Mueller AJ, Proikas-Cezanne T (2019) Methods Mol Biol 1880:429-445. Abstract

 

2018

[2] Lysosomal proteome and secretome analysis identifies missorted enzymes and their non-degraded substrates in mucolipidosis III mouse cells.  Di Lorenzo G, Voltolini Velho R, Winter D, Thelen M, Ahmadi S, Schweizer M, De Pace R, Cornils K, Yorgan TA, Grüb S, Hermans-Borgmeyer I, Schinke T, Müller-Loennies S, Braulke T, Pohl S (2018) Mol Cell Proteomics 17:1612-26. Abstract 

[1] SGK1 Inhibits Autophagy in Murine Muscle Tissue. Zuleger T, Heinzelbecker J, Takacs Z, Hunter C, Voelkl J, Lang F, Proikas-Cezanne T (2018) Oxid Med Cell Longev 2018:4043726. Abstract