Judith Klumperman

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Judith Klumperman

PI of Research Project 4:
“Mannose 6-phosphate receptor independent transport of lysosomal proteins”

CONTACT

Prof. Dr. Judith Klumperman

University Medical Center Utrecht
Department of Cell Biology
Heidelberglaan 100
CX-Utrecht
The Netherlands

phone: + 31 88 755 6550
fax: + 31 88 755 5590
e-Mail j.klumperman@umcutrecht.nl
website Klumperman Lab

 

 

 

 

KEY PUBLICATIONS

The Complex Ultrastructure of the Endolysosomal System. Klumperman J, Raposo G (2014) Cold Spring Harb Perspect Biol 6:a016857

hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins. Pols M, van Meel E, Oorschot V, ten Brink C, Fukuda M, Swetha MG, Mayor S, Klumperman J (2013) Nat Commun 4:1361

The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion. Pols MS, ten Brink C, Gosavi P, Oorschot V, Klumperman J (2013) Traffic 14:219-32

Lysosomal protein composition, acidic pH and sterol content are regulated by a Light-dependent pathway in metazoan cells. Swetha MG, Sriram V, Krishnan KS, Oorschot VMJ, ten Brink C, Klumperman J, Mayor S (2011) Traffic 12:1037-55

Architecture of the mammalian Golgi. Klumperman J (2011) Cold Spring Harb Perspect Biol 3:a005181

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function. Saftig P, Klumperman J (2009) Nat Rev Mol Cell Biol 10:623-35

A novel correlative light-electron microscopy (CLEM) method integrating live-cell imaging and immunolabeling of ultrathin cryosections. van Rijnsoever C, Oorschot V, Klumperman J (2008) Nat Methods 5:973-80

Immuno-electron tomography reveals the existence of free COPII-coated transport carriers. Zeuschner D, Geerts WJC, van Donselaar E, Humbel. B, Slot JW, Koster AJ,
Klumperman J (2006) Nat Cell Biol 8:377-83

The maturing role of COPI vesicles in intra-Golgi transport. Rabouille C, Klumperman J (2005) Nat Rev Mol Cell Biol 6:812-7

Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins. Peden AA, Oorschot V, Hesser, B, Austin CD, Scheller RH, Klumperman J (2004) J Cell Biol 164:1065-76