Tobias Stauber


Tobias Stauber

PI of Research Project 6:
“Lysosomal chloride and membrane traffic of and to lysosomes”


PD Dr. Tobias Stauber

Freie Universität Berlin
Institut für Chemie und Biochemie
Thielallee 63
D-13125 Berlin

phone: +49 (0) 30 838 54069
fax: +49 (0) 30 838 454069
website Stauber Lab






Identification of LRRC8 heteromers as an essential component of the volume‐regulated anion channel VRAC. Voss FK, Ullrich F, Münch J, Lazarow K, Lutter D, Mah N, Andrade‐Navarro MA, von Kries JP, Stauber T*, Jentsch TJ* (2014) Science 344:634‐8 (*corresponding authors)

A missense mutation accelerating the gating of the lysosomal Cl/H+ exchanger ClC‐7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle. Sartelet A*, Stauber T*, Coppieters W, Ludwig CF, Fasquelle C, Druet T, Zhang Z, Ahariz N, Cambisano N, Jentsch TJ§, Charlier C§ (2014) Dis Model Mech 7:119‐28 (*equal contribution, §corresponding authors)

Chloride in vesicular trafficking and function. Stauber T, Jentsch TJ (2013) Annu Rev Physiol 75:453-77

ClC‐7 is a slowly voltage-gated 2Cl/1H+‐exchanger and requires Ostm1 for transport activity. Leisle L, Ludwig CF, Wagner FA, Jentsch TJ, Stauber T (2011) EMBO J 30:2140‐52

Stauber T, Jentsch TJ (2010) Sorting motifs of the endosomal/lysosomal CLC chloride transporters. J Biol Chem 285:34537‐48

The G215R mutation in the Cl/H+‐antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. Schulz P, Werner J, Stauber T, Henriksen K, Fendler K (2010) PLoS One 5:e12585

Lysosomal pathology and osteopetrosis upon loss of H+‐driven lysosomal Cl accumulation. Weinert S, Jabs S, Supanchart C, Schweizer M, Gimber N, Richter M, Rademann J, Stauber T, Kornak U, Jentsch TJ (2010) Science 328:1401‐3

A cation counterflux supports lysosomal acidification. Steinberg BE, Huynh KK, Brodovitch A, Jabs S, Stauber T, Jentsch TJ, Grinstein S (2010) J Cell Biol 189:1171‐86

A role for kinesin‐2 in COPI-dependent recycling between the ER and the Golgi complex. Stauber T, Simpson JC, Pepperkok R, Vernos I (2006) Curr Biol 16:2245‐51

Kinesin-2 is a motor for late endosomes and lysosomes. Brown CL, Maier KC, Stauber T, Ginkel LM, Wordemann L, Vernos I, Schroer TA (2005) Traffic 6:1114-24