Tobias Stauber


Tobias Stauber

PI of Research Project 6:
“Cell type-specific roles of chloride/proton exchange in lysosomes”


Prof. Dr. Tobias Stauber

Medical School Hamburg
Department Humanmedizin
Am Kaiserkai 1
D-20457 Hamburg

phone: +49 (0) 40 361 2264 9283
fax: +49 (0) 40 361 2264 30
website Stauber Lab






A mathematical model of lysosomal ion homeostasis points to differential effects of Cl transport in Ca2+. Astaburuaga R, Quintanar Haro OD, Stauber T*, Relógio A* (2019) Cells 8:E1263. (*corresponding authors)

The LRRC8/VRAC anion channel facilitates myogenic differentiation of murine myoblasts by promoting membrane hyperpolarization. Chen L, Becker TM, Koch U, Stauber T (2019) J Biol Chem 294:14279-88.

A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength. König B, Hao Y, Schwartz S, Plested AJR, Stauber T (2019) Elife 8:e45421.

Identification of LRRC8 heteromers as an essential component of the volume‐regulated anion channel VRAC. Voss FK, Ullrich F, Münch J, Lazarow K, Lutter D, Mah N, Andrade‐Navarro MA, von Kries JP, Stauber T*, Jentsch TJ* (2014) Science 344:634‐8. (*corresponding authors)

A missense mutation accelerating the gating of the lysosomal Cl/H+ exchanger ClC‐7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle. Sartelet A*, Stauber T*, Coppieters W, Ludwig CF, Fasquelle C, Druet T, Zhang Z, Ahariz N, Cambisano N, Jentsch TJ§, Charlier C§ (2014) Dis Model Mech 7:119‐28. (*equal contribution, §corresponding authors)

ClC‐7 is a slowly voltage-gated 2Cl/1H+‐exchanger and requires Ostm1 for transport activity. Leisle L, Ludwig CF, Wagner FA, Jentsch TJ, Stauber T (2011) EMBO J 30:2140‐52.

Sorting motifs of the endosomal/lysosomal CLC chloride transporters. Stauber T, Jentsch TJ (2010) J Biol Chem 285:34537‐48.

Lysosomal pathology and osteopetrosis upon loss of H+‐driven lysosomal Cl accumulation. Weinert S, Jabs S, Supanchart C, Schweizer M, Gimber N, Richter M, Rademann J, Stauber T, Kornak U, Jentsch TJ (2010) Science 328:1401‐3.

A cation counterflux supports lysosomal acidification. Steinberg BE, Huynh KK, Brodovitch A, Jabs S, Stauber T, Jentsch TJ, Grinstein S (2010) J Cell Biol 189:1171‐86.

A role for kinesin‐2 in COPI-dependent recycling between the ER and the Golgi complex. Stauber T, Simpson JC, Pepperkok R, Vernos I (2006) Curr Biol 16:2245‐51.