Christian Hübner
PI of Research Project 3:
“The role of AP-5 in the endolysosomal system, autophagy and autophagic lysosome reformation”
CONTACT
Prof. Dr. Christian Hübner
Universitätsklinikum Jena
Institut für Humangenetik
Am Klinikum 1, FUI, Haus F, Ebene 20
D-07747 Jena
Germany
phone: +49 (0) 3641 9-396800
fax: +49 (0) 3641 9-396802
christian.huebner@med.uni-jena.de
website Hübner Lab
KEY PUBLICATIONS
Regulation of endoplasmic reticulum turnover by selective autophagy. Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I*, Hübner CA*, Dikic I* (2015) Nature 522:354-8. (*equal contribution and shared senior authorship)
Disruption of vascular Ca2+-activated chloride currents lowers blood pressure. Heinze C, Seniuk A, Sokolov MV, Huebner AK, Klementowicz AE, Szijártó IA, Schleifenbaum J, Vitzthum H, Gollasch M, Ehmke H, Schroeder BC, Hübner CA (2014) J Clin Invest 124:675-86.
A spastic paraplegia mouse model reveals REEP1-dependent ER shaping. Beetz C, Koch N, Khundadze M, Zimmer G, Nietzsche S, Hertel N, Huebner AK, Mumtaz R, Schweizer M, Dirren E, Karle KN, Irintchev A, Alvarez V, Redies C, Westermann M, Kurth I, Deufel T, Kessels MM, Qualmann B, Hübner CA (2013) J Clin Invest 123:4273-82.
A de novo gain-of-function mutation in SCN11A causes loss of pain perception. Leipold E, Liebmann L, Korenke GC, Heinrich T, Giesselmann S, Baets J, Ebbinghaus M, Goral RO, Stödberg T, Hennings JC, Bergmann M, Altmüller J, Thiele H, Wetzel A, Nürnberg P, Timmerman V, De Jonghe P, Blum R, Schaible HG, Weis J, Heinemann SH, Hübner CA, Kurth I (2013) Nat Genet 45:1399-04.
The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. Leviel F*, Hübner CA*, Morla L, Houillier P, El Moghrabi S, Brideau G, Hatim H, Kurth I, Kougioumtzes A, Sinning A, Pech V, Riemondy KA, Miller RL, Hummler E, Shull GE, Aronson PS, Doucet A, Wall SM, Chambrey R, Eladari D (2010) J Clin Invest 120:1627-35. (*equal contribution)
Mutations in FAM134B, encoding a novel Golgi protein, cause severe sensory and autonomic neuropathy. Kurth I, Pamminger T, Hennings JC, Soehendra D, Huebner AK, Rotthier A, Baets J, Senderek J, Topaloglu H, Farrel SA, Nürnberg P, De Jonghe P, Gal A, Kaether C, Timmerman V, Hübner CA (2009) Nat Genet 41:1179-81.
Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Jacobs S, Ruusuvuori E, Sipilä S, Hapaanen A, Damkier HH, Kurth I, Hentschke M, Schweizer M, Rudhard Y, Laatinkainen L, Tyynelä J, Praetorius J, Voipio J, Hübner CA (2008) Proc Natl Acad Sci U S A 105:311-6.
Disruption of erythroid K-Cl co-transporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice. Rust MB, Alper SL, Rudhard Y, Brugnara C, Trudel M, Jentsch TJ, Hübner CA (2007) J Clin Invest 117:1708-17.
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter KCC4. Boettger T*, Hübner CA*, Maier H, Rust M, Beck FX, Jentsch TJ (2002) Nature 416:874-8. (*equal contribution)
Disruption of KCC2 reveals an essential role of K-Cl-cotransport already in early synaptic inhibition. Hübner CA, Stein V, Hermans-Borgmeyer I, Meyer T, Ballanyi K, Jentsch TJ (2001) Neuron 30:515-24.