Thomas Jentsch

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Thomas J. Jentsch

PI of Research Project 6:
“Lysosomal chloride and membrane traffic of and to lysosomes”

CONTACT

Prof. Dr. Dr. Thomas J. Jentsch

Leibniz-Forschungsinstitut für Molekulare Pharmakologie und
Max-Delbrück-Centrum für Molekulare Medizin
Robert-Rössle-Strasse 10
D-13125 Berlin
Germany

phone: +49 (0) 30 9406 2961
fax: +49 (0) 30 9406 2960
jentsch@fmp-berlin.de
website Jentsch Lab

 

 

 

 

KEY PUBLICATIONS

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs. Planells-Cases R, Lutter D, Guyader C, Gerhards NM, Ullrich F, Elger DA, Kucukosmanoglu A, Xu G, Voss FK, Reincke SM, Stauber T, Blomen VA, Vis DJ, Wessels LF, Brummelkamp TR, Borst P, Rottenberg S, Jentsch TJ (2015)  EMBO J 34: 2993-3008

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Voss FK, Ullrich F, Münch J, Lazarow K, Lutter D, Mah N, Andrade-Navarro MA, von Kries JP, Stauber T*, Jentsch TJ* (2014)  Science 344:634-8 (*corresponding authors)

Ca2+-activated Cl currents are dispensable for olfaction. Billig GM, Pál B, Fidzinski P, Jentsch TJ (2011) Nat Neurosci 14:763-9

Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl accumulation. Weinert S, Jabs S, Supanchart C, Schweizer M, Gimber N, Richter M, Rademann J, Stauber T, Kornak U, Jentsch TJ (2010) Science 328:1401-3

Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis. Novarino G, Weinert S, Rickheit G, Jentsch TJ (2010)  Science 328:1398-401

ClC-7 requires Ostm1 as a β-subunit to support bone resorption and lysosomal function. Lange PF, Wartosch L, Jentsch TJ*, Fuhrmann JC (2006) Nature 440:220-3 (*corresponding author)

Voltage-dependent electrogenic chloride-proton exchange by endosomal CLC proteins. Scheel O, Zdebik AA, Lourdel S, Jentsch TJ (2005) Nature 436:424-7

Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration. Kasper D, Planells-Cases R, Fuhrmann JC, Scheel O, Zeitz O, Ruether K, Schmitt A, Poët M, Steinfeld R, Schweizer M, Kornak U, Jentsch TJ (2005) EMBO J 24:1079-91

Barttin is a Cl channel b-subunit crucial for renal Cl reabsorption and inner ear K+ secretion. Estévez R, Boettger T, Stein V, Birkenhäger R, Otto E, Hildebrandt F, Jentsch TJ (2001)  Nature 414:558-61

Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Kornak U, Kasper D, Bösl MR, Kaiser E, Schweizer M, Schulz A, Friedrich W, Delling G, Jentsch TJ (2001)  Cell 104:205-15