Thomas Braulke

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Thomas Braulke

Speaker of the FOR 2625

PI of Research Project 7:
“Adaptive lysosomal signaling mechanisms in CLN3-defective cells”

CONTACT

Prof. Dr. Thomas Braulke

University Medical Center Hamburg-Eppendorf
Children’s Hospital – Section Biochemistry
Martinistr. 52, Bldg. N27
D-20246 Hamburg
Germany

phone: +49 40 7410 54493
fax: +49 40 7410 58504
braulke@uke.de
website Braulke Lab

 

 

 

 

KEY PUBLICATIONS


Mannose 6-phosphorylation of lysosomal enzymes controls B-cell functions.
Otomo T, Schweizer M, Kollmann K, Schumacher V, Muschol N, Tolosa E, Mittrücker HW, Braulke T* (2015) J Cell Biol 208:171-80 (*corresponding author)

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, Peterson BS, Xu G, Ilkayeva OR, Muehlbauer MJ, Braulke T, Mühlhausen C, Backos DS, Olsen CA, McGuire PJ, Pletcher SD, Lombard DB, Hirschey MD, Zhao Y (2014)  Cell Metab 19:605-17

Increased osteoclastogenesis rather than missorting of lysosomal enzymes is causing bone loss in mucolipidosis II. Kollmann K, Pestka JM, Schöne E, Schweizer M, Karkmann K, Kühn SC, Catala-Lehnen P, Failla AV, Marshall RP, Krause M, Santer R, Amling M, Braulke T*, Schinke T* (2013)  EMBO Mol Med 5:1871-86 (*corresponding author)

Storage material and lysosomal dysfunction cause neurodegeneration in mucolipidosis II knockin mice. Kollmann K, Damme M, Markmann S, Morelle W, Schweizer M, Hermans-Borgmeyer I, Röchert AK, Pohl S, Lübke T, Michalski J-C, Käkelä R, Walkley SU, Braulke T* (2012) Brain 135:2661-75 (*corresponding author)

Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5. Makrypidi G, Damme M, Müller-Loennies S, Trusch M, Schmidt B, Schlüter H, Heeren J, Lübke T, Saftig P, Braulke T* (2012) Mol Cell Biol 32:774-82 (*corresponding author)

A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism. Marschner K, Kollmann K, Schweizer M, Braulke T*, Pohl S (2011) Science 333:87-90 (*corresponding author)

A novel single chain antibody fragment for detection of mannose 6-phosphate-containing proteins. Application in mucolipidosis type II patients and mice. Müller-Loennies S, Galliciotti G, Kollmann K, Glatzel M, Braulke T* (2010) Am J Pathol 177:240-7 (*corresponding author)

Mucolipidosis II is caused by mutations in GNPTA encoding the alpha/beta GlcNAc-1-phosphotransferase. Tiede S, Storch S, Lübke T, Henrissat B, Bargal R, Raas-Rothschild A, Braulke T* (2005) Nat Med 11:1109-12 (*corresponding author)

Synthesis of insulin-like growth factor binding proteins and of the acid-labile subunit in primary cultures of rat hepatocytes, of Kupffer cells, and in cocultures: regulation by insulin, insulin-like growth factor, and growth hormone. Scharf J, Ramadori G, Braulke T, Hartmann H (1996) Hepatology 23:818-27

Regulation of mannose 6-phosphate/IGFII receptor expression at the cell surface by mannose 6-phosphate, insulin-like growth factors and epidermal growth factor. Braulke T, Tippmer S, Neher E, von Figura K (1989) EMBO J 8:681-6