Ivan Dikic

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Ivan Dikic

PI of Research Project 5:
“Ubiquitin signaling regulating lysosome functions”

 

CONTACT

Prof. Dr. Ivan Dikic

Goethe-Universität Frankfurt
Institut für Biochemie II
Theodor-Stern-Kai 7
D-60590 Frankfurt a. M.
Germany

phone: +49 (0) 69 6301 5652
fax: +49 (0) 69 6301 5577
ivan.dikic@biochem2.de
website Dikic Lab

 

 

KEY PUBLICATIONS

Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA. Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I (2017) Nat Commun 8:14004

Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination. Bhogaraju S, Kalayil S, Liu Y, Bonn F, Colby T, Matic I, Dikic I (2016) Cell 167:1636-1649.e13

Global Analysis of Host and Bacterial Ubiquitinome in Response to Salmonella Typhimurium Infection. Fiskin E, Bionda T, Dikic I, Behrends C (2016) Mol Cell 62:967-81

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I (2016) Proc Natl Acad Sci U S A pii: 201523926

PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins. McEwan DG, Popovic D, Gubas A, Terawaki S, Suzuki H, Stadel D, Coxon FP, Miranda de Stegmann D, Bhogaraju S, Maddi K, Kirchof A, Gatti E, Helfrich MH, Wakatsuki S, Behrends C, Pierre P, Dikic I (2015) Mol Cell 57:39-54

PLEKHM1 Regulates Salmonella-Containing Vacuole Biogenesis and Infection. McEwan DG, Richter B, Claudi B, Wigge C, Wild P, Farhan H, McGourty K, Coxon FP, Franz-Wachtel M, Perdu B, Akutsu M, Habermann A, Kirchof A, Helfrich MH, Odgren PR, Van Hul W, Frangakis AS, Rajalingam K, Macek B, Holden DW, Bumann D, Dikic I (2015) Cell Host Microbe 17:58-71

Binding of OTULIN to the PUB domain of HOIP controls NF-kappaB signaling. Schaeffer V, Akutsu M, Olma MH, Gomes LC, Kawasaki M, Dikic I (2014) Mol Cell 54:349-61

Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP. Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I, Rittinger K (2013) Nature 503:422-6

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, Brady NR, Richter B, Korac J, Waidmann O, Choudhary C, Dötsch V, Bumann D, Dikic I (2011) Science 333:228-33

SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis. Ikeda F, Deribe YL, Skanland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I (2011) Nature 471:637-41