Ivan Dikic
PI of Research Project 5:
“Ubiquitination in regulation of lysosome functions”
CONTACT
Prof. Dr. Ivan Dikic
Goethe-Universität Frankfurt
Institut für Biochemie II
Theodor-Stern-Kai 7
D-60590 Frankfurt a. M.
Germany
phone: +49 (0) 69 6301 5652
fax: +49 (0) 69 6301 5577
ivan.dikic@biochem2.de
website Dikic Lab
KEY PUBLICATIONS
Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB. Shin D, Mukherjee R, Liu Y, Gonzalez A, Bonn F, Liu Y, Rogov VV, Heinz M, Stolz A, Hummer G, Dötsch V, Luo ZQ, Bhogaraju S, Dikic I (2020) Mol Cell 77:164-79.
Cellular quality control by the ubiquitin-proteasome system and autophagy. Pohl C, Dikic I (2019) Science 366:818-22.
Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin-catalysed glutamylation. Bhogaraju S, Bonn F, Mukherjee R, Adams M, Pfleiderer MM, Galej WP, Matkovic V, Lopez-Mosqueda J, Kalayil S, Shin D, Dikic I (2019) Nature 572:382-6.
Deubiquitinase USP10 regulates Notch signaling in the endothelium. Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M (2019) Science 364:188-93.
Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination. Kalayil S, Bhogaraju S, Bonn F, Shin D, Liu Y, Gan N, Basquin J, Grumati P, Luo ZQ, Dikic I (2018) Nature 557:734-8.
Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination. Bhogaraju S, Kalayil S, Liu Y, Bonn F, Colby T, Matic I, Dikic I (2016) Cell 167:1636-1649.e13.
Regulation of endoplasmic reticulum turnover by selective autophagy. Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I (2015) Nature 522:354-8.
Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP. Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I, Rittinger K (2013) Nature 503:422-6
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, Brady NR, Richter B, Korac J, Waidmann O, Choudhary C, Dötsch V, Bumann D, Dikic I (2011) Science 333:228-33
SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis. Ikeda F, Deribe YL, Skanland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I (2011) Nature 471:637-41.