Mukhran Khundadze
Associated PI of Research Project 3:
“The role of AP-5 in the endolysosomal system, autophagy and autophagic lysosome reformation”
CONTACT
Dr. Mukhran Khundadze
Universitätsklinikum Jena
Institut für Humangenetik
Am Klinikum 1, FUI, Haus F, Ebene 20
D-07747 Jena
Germany
phone: +49 (0) 3641 9-396881
fax: +49 (0) 3641 9-396802
mukhran.khundadze@med.uni-jena.de
website Hübner Lab
KEY PUBLICATIONS
The spectrum of KIAA0196 variants, and characterization of a murine knockout: implications for the mutational mechanism in hereditary spastic paraplegia type SPG8. Jahic A, KhundadzeM, Jaenisch N, Schüle R, Klimpe S, Klebe S, Frahm C, Kassubek J, Stevanin G, Schöls L, Brice A, Hübner CA, Beetz C (2015) Orphanet J Rare Dis 10:147
In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11. Varga RE*, Khundadze M*, Damme M, Nietzsche S, Hoffmann B, Stauber T, Koch N, Hennings JC, Franzka P, Huebner AK, Kessels MM, Biskup C, Jentsch TJ, Qualmann B, Braulke T, Kurth I, Beetz C, Hübner CA (2015) PLoS Genet 11:e1005454 (*equal contribution)
Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions. Gerstmann K, Pensold D, Symmank J, Khundadze M, Hübner CA, Bolz J, Zimmer G (2015) Development 142:140-50
A Hereditary Spastic Paraplegia Mouse Model Supports a Role of ZFYVE26 /SPASTIZIN for the Endolysosomal System. Khundadze M, Kollmann K, Koch N, Biskup C, Nietzsche S, Zimmer G, Hennings JC, Huebner AK, Symmank J, Jahic A, Ilina EI, Karle K, Schols L, Kessels M, Braulke T, Qualmann B, Kurth I, Beetz C, Hübner CA (2013) PLoS Genet. 9:e1003988
A spastic paraplegia mouse model reveals REEP1-dependent ER shaping. Beetz C, Koch N, Khundadze M, Zimmer G, Nietzsche S, Hertel N, Huebner AK, Mumtaz R, Schweizer M, Dirren E, Karle KN, Irintchev A, Alvarez V, Redies C, Westermann M, Kurth I, Deufel T, Kessels MM, Qualmann B, Hübner CA (2013) J Clin Invest 123:4273 – 82
L-NAME has opposite effects on the productions of S-adenosylhomocysteine and S-adenosyl-methionine in V12-H-Ras and M-CR3B-Ras pheochromocytoma cells. Sephashvili M, Zhuravliova E, Barbakadze T, Khundadze M, Narmania N, Mikeladze DG (2006) Neurochem Res 31:1205-10