Paul Saftig

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Paul Saftig

PI of Research Project 9:
“Understanding the role of the Lysosomal Integral Membrane Protein type 2
(LIMP-2/SCARB2) in lysosomal lipid transport

 

CONTACT

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KEY PUBLICATIONS

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LAMP-2B Reverses Metabolic and Physiologic Multiorgan Dysfunction in a Murine Model of Danon Disease. Manso AM, Hashem S, Nelson B, Gault E, Soto-Hermida A, Villarruel E, Brambatti M, Bushway PJ, Chen C, Battiprolu P, Keravala A, Schwartz JD, Shah G, Gu Y, Dalton ND, Hammond K, Peterson K, Saftig P, Adler ED (2020) Sci Transl Med 12:eaax1744.

Lysosomal Integral Membrane Protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export. Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Wenig X, Kim YA, Collins RA, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S*, Ikonen E*, Saftig P*, Neculai D* (2019) Nat Commun 10:3521. (*corresponding author)

Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis. Marques ARA, Di Spiezio A, Thießen T, Schmidt L, Grötzinger J, Lüllmann-Rauch R, Damme M, Storck SE, Pietrzik CU, Fogh J, Bär J, Mikhaylova M, Glatzel M, Bassal M, Bartsch U, Saftig P (2019) Autophagy 16:1-15.

Virus entry. Lassa virus entry requires a trigger-induced receptor switch. Jae LT, Raaben M, Herbert AS, Kuehne AI, Wirchnianski AS, Soh TK, Stubbs SH, Janssen H, Damme M, Saftig P, Whelan SP, Dye JM, Brummelkamp TR (2014) Science 344:1506-10.

Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by 2 structural, biophysical and cellular studies. Conrad KS, Cheng TW, Ysselstein D, Heybrock S, Hoth LR, Chrunyk BA, am Ende CW, Krainc D, Schwake M, Saftig P, Liu S, Qiu X, Ehlers M (2017) Nat Commun 8:1908.

Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Neculai D, Schwake M, Ravichandran M, Zunke F, Collins R, Peters J, Neculai M, Plumb J, Loppnau P, Pizarro JC, Seitova A, Trimble WS, Saftig P, Grinstein S, Dhe-Paganon S (2013) Nature 504:172-6.

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function. Saftig P, Klumperman J (2009) Nat Rev Mol Cell Biol 10:623-35.

LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase. Reczek D, Schwake M, Schröder J, Hughes H, Blanz J, Jin X, Brondyk W, Van Patten S, Edmunds T, Saftig P (2007) Cell 131:770-83.

Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2 deficient mice. Tanaka Y, Guhde G, Suter A, Eskelinen EL, Hartmann D, Lullmann-Rauch R, Janssen PM, Blanz J, von Figura K, Saftig P (2000) Nature 406:902-6.

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. De Strooper B, Saftig P*, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, von Figura K, van Leuven F (1998) Nature 391:387-90. (*equal contribution)