Paul Saftig

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Paul Saftig

PI of Research Project 2:
“Deciphering the physiological roles of the lysosomal phosphatidylinositol- 4,5-bisphosphate 4-phosphatases TMEM55A and TMEM55B

 

CONTACT

Prof. Dr. Paul Saftig

Christian-Albrechts-Universität zu Kiel
Biochemisches Institut
Olshausenstr. 40
D-24098 Kiel
Germany

phone: 49 (0) 431 880 2216
fax: +49 (0) 431 880 2238
e-Mail psaftig@biochem.uni-kiel.de
website Saftig Lab

 

 

 

 

KEY PUBLICATIONS


Virus entry. Lassa virus entry requires a trigger-induced receptor switch. Jae LT, Raaben M, Herbert AS, Kuehne AI, Wirchnianski AS, Soh TK, Stubbs SH, Janssen H, Damme M, Saftig P, Whelan SP, Dye JM, Brummelkamp TR (2014) Science 344:1506-10

Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Neculai D, Schwake M, Ravichandran M, Zunke F, Collins R, Peters J, Neculai M, Plumb J, Loppnau P, Pizarro JC, Seitova A, Trimble WS, Saftig P, Grinstein S, Dhe-Paganon S (2013) Nature 504:172-6

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function. Saftig P, Klumperman J (2009) Nat Rev Mol Cell Biol 10:623-35

Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H (2008) Science 319:624-7

LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase. Reczek D, Schwake M, Schröder J, Hughes H, Blanz J, Jin X, Brondyk W, Van Patten S, Edmunds T, Saftig P (2007) Cell 131:770-83

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, Mignot G, Maiuri MC, Ullrich E, Saulnier P, Yang H, Amigorena S, Ryffel B, Barrat FJ, Saftig P, Levi F, Lidereau R, Nogues C, Mira JP, Chompret A, Joulin V, Clavel-Chapelon F, Bourhis J, André F, Delaloge S, Tursz T, Kroemer G, Zitvogel L (2007) Nat Med 13:1050-9

Control of peripheral nerve myelination by the beta-secretase BACE1. Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C (2006) Science 314:664-6

Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2 deficient mice. Tanaka Y, Guhde G, Suter A, Eskelinen EL, Hartmann D, Lullmann-Rauch R, Janssen PM, Blanz J, von Figura K, Saftig P (2000) Nature 406:902-6

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R (1999) Nature 398:518-22

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. De Strooper B, Saftig P*, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, von Figura K, van Leuven F (1998) Nature 391:387-90 (*equal contribution)