Christian Hübner

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Christian Hübner

PI of Research Project 3:

“The role of AP-5 in the endolysosomal system, autophagy and autophagic lysosome reformation”

 

CONTACT

Prof. Dr. Christian Hübner

Universitätsklinikum Jena
Institut für Humangenetik
Am Klinikum 1, FUI, Haus F, Ebene 20
D-07747 Jena
Germany

phone: +49 (0) 3641 9-396800
fax: +49 (0) 3641 9-396802
e-Mail christian.huebner@med.uni-jena.de
website Hübner Lab

 

 

KEY PUBLICATIONS

Disruption of KCC2 reveals an essential role of K-Cl-cotransport already in early synaptic inhibition. Hübner CA, Stein V, Hermans-Borgmeyer I, Meyer T, Ballanyi K, Jentsch TJ (2001) Neuron 30:515-24

Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter KCC4. Boettger T*, Hübner CA*, Maier H, Rust M, Beck FX, Jentsch TJ (2002) Nature 416:874-8 (*equal contribution)

Disruption of erythroid K-Cl co-transporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice. Rust MB, Alper SL, Rudhard Y, Brugnara C, Trudel M, Jentsch TJ, Hübner CA (2007) J Clin Invest 117:1708-17

Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability. Jacobs S, Ruusuvuori E, Sipilä S, Hapaanen A, Damkier HH, Kurth I, Hentschke M, Schweizer M, Rudhard Y, Laatinkainen L, Tyynelä J, Praetorius J, Voipio J, Hübner CA (2008) Proc Natl Acad Sci U S A 105:311-6

Mutations in FAM134B, encoding a novel Golgi protein, cause severe sensory and autonomic neuropathy. Kurth I, Pamminger T, Hennings JC, Soehendra D, Huebner AK, Rotthier A, Baets J, Senderek J, Topaloglu H, Farrel SA, Nürnberg P, De Jonghe P, Gal A, Kaether C, Timmerman V, Hübner CA (2009) Nat Genet 41:1179-81

Identification of a novel amiloride-resistant, thiazide-sensitive NaCl reabsorption pathway in the distal nephron. Leviel F*, Hübner CA*, Morla L, Houillier P, El Moghrabi S, Brideau G, Hatim H, Kurth I, Kougioumtzes A, Sinning A, Pech V, Riemondy KA, Miller RL, Hummler E, Shull GE, Aronson PS, Doucet A, Wall SM, Chambrey R, Eladari D (2010) J Clin Invest 120:1627-35 (*equal contribution)

A de novo gain-of-function mutation in SCN11A causes loss of pain perception. Leipold E, Liebmann L, Korenke GC, Heinrich T, Giesselmann S, Baets J, Ebbinghaus M, Goral RO, Stödberg T, Hennings JC, Bergmann M, Altmüller J, Thiele H, Wetzel A, Nürnberg P, Timmerman V, De Jonghe P, Blum R, Schaible HG, Weis J, Heinemann SH, Hübner CA, Kurth I (2013) Nat Genet 45:1399-04

A spastic paraplegia mouse model reveals REEP1-dependent ER shaping. Beetz C, Koch N, Khundadze M, Zimmer G, Nietzsche S, Hertel N, Huebner AK, Mumtaz R, Schweizer M, Dirren E, Karle KN, Irintchev A, Alvarez V, Redies C, Westermann M, Kurth I, Deufel T, Kessels MM, Qualmann B, Hübner CA (2013) J Clin Invest 123:4273-82

Disruption of vascular Ca2+-activated chloride currents lowers blood pressure. Heinze C, Seniuk A, Sokolov MV, Huebner AK, Klementowicz AE, Szijártó IA, Schleifenbaum J, Vitzthum H, Gollasch M, Ehmke H, Schroeder BC, Hübner CA (2014) J Clin Invest 124:675-86

Regulation of endoplasmic reticulum turnover by selective autophagy. Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I*, Hübner CA*, Dikic I* (2015) Nature 522:354-8 (*equal contribution and shared senior authorship)