Anja Bremm

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Anja Bremm

PI of Research Project 5:
“Ubiquitin signaling regulating lysosome functions”

 

CONTACT

Dr. rer. nat. Anja Bremm

Goethe-Universität Frankfurt
Buchmann Institut für Molekulare Lebenswissenschaften
Institut für Biochemie II
Max-von-Laue-Str. 15
D-60438 Frankfurt a. M.
Germany

phone: +49 (0) 69 798 42510
fax: +49 (0) 69 798 763 42510
e-Mail bremm@em.uni-frankfurt.de
website Bremm Lab

 

 

KEY PUBLICATIONS

Ubiquitin chain diversity at a glance. Akutsu M, Dikic I, Bremm A (2016) J Cell Sci 129:875-80

Cezanne regulates E2F1-dependent HIF2α expression. Moniz S, Bandarra D, Biddlestone J, Campbell KJ, Komander D, Bremm A, Rocha S (2015) J Cell Sci 128:3082-93

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner. Bremm A, Moniz S, Mader J, Rocha S, Komander D (2014) EMBO Rep 15:1268-77

DUBs counteract parkin for efficient mitophagy. Dikic I, Bremm A (2014) EMBO J 33:2442-3

Synthesis and analysis of K11-linked ubiquitin chains. Bremm A, Komander D (2012) Methods Mol Biol 832:219-28

Emerging roles for Lys11-linked polyubiquitin in cellular regulation. Bremm A, Komander D (2012) Trends Biochem Sci 36:355-63

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Bremm A, Freund SM, Komander D (2010) Nat Struct Mol Biol 17:939-47

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain. Kulathu Y, Akutsu M*, Bremm A*, Hofmann K, Komander D (2009) Nat Struct Mol Biol 16:1328-30 (*equal contribution)

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Markson G, Kiel C, Hyde R, Brown S, Charalabous P, Bremm A, Semple J, Woodsmith J, Duley S, Salehi-Ashtiani K, Vidal M, Komander D, Serrano L, Lehner P, Sanderson CM (2009) Genome Res 19:1905-11

Enhanced activation of epidermal growth factor receptor caused by tumor-derived E-cadherin mutations. Bremm A, Walch A, Fuchs M, Mages J, Duyster J, Keller G, Hermannstädter C, Becker KF, Rauser S, Langer R, von Weyhern CH, Höfler H, Luber B (2008) Cancer Res 68:707-1