Markus Damme


Markus Damme

PI of Research Project 2:
“Deciphering the physiological roles of the lysosomal phosphatidylinositol- 4,5-bisphosphate 4-phosphatases TMEM55A and TMEM55B”



PD Dr. Markus Damme

Christian-Albrechts-Universität zu Kiel
Biochemisches Institut
Olshausenstr. 40
D-24098 Kiel

phone: 49 (0) 431 880 2218
fax: +49 (0) 431 880 2238
website Damme Group






Quantitative proteome analysis of mouse liver lysosomes provides evidence for mannose 6-phosphate-independent targeting mechanisms of acid hydrolases in mucolipidosis II. Markmann S*, Krambeck S*, Hughes CJ, Mirzaian M, Aerts JM, Saftig P, Schweizer M, Vissers JC, Braulke T, Damme M (2017) Mol Cell Proteomics mcp.M116.063636. doi: 10.1074/mcp.M116.063636 (*equal contribution)

Ataxia is the major neuropathological finding in Arylsulfatase G deficient mice: Similarities and dissimilarities to Sanfilippo disease (Mucopolysaccharidosis type III). Kowalewski B, Heimann P, Ortkras T, Lüllmann-Rauch R, Sawada T, Walkley SU, Dierks T, Damme M (2015)  Hum Mol Genet 24:1856-68

Autophagy in neuronal cells: general principles and physiological and pathological functions. Damme M, Suntio T, Saftig P, Eskelinen EL (2014)  Acta Neuropathol 129:337-62

Molecular Characterization of Arylsulfatase G: Expression, Processing, Glycosylation, Transport, and Activity. Kowalewski B, Lübke T, Kollmann K, Braulke T, Reinheckel T, Dierks T, Damme M (2014)  J Biol Chem 289:27992-8005

Virus entry. Lassa virus entry requires a trigger-induced receptor switch. Jae LT, Raaben M, Herbert AS, Kuehne AI, Wirchnianski AS, Soh TK, Stubbs SH, Janssen H, Damme M, Saftig P, Whelan SP, Dye JM, Brummelkamp TR (2014)  Science 344:1506-10

Lysosomal dysfunction causes neurodegeneration in mucolipidosis II ‘knock-in’ mice. Kollmann K*, Damme M*, Markmann S, Morelle W, Schweizer M, Hermans-Borgmeyer I, Röchert AK, Pohl S, Lübke T, Michalski JC, Käkelä R, Walkley SU, Braulke T (2012)  Brain 135:2661-75 (*equal contribution)

Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice. Kowalewski B, Lamanna WC*, Lawrence R*, Damme M*, Stroobants S, Padva M, Kalus I, Frese MA, Lübke T, Lüllmann-Rauch R, D’Hooge R, Esko JD, Dierks T (2012)  Proc Natl Acad Sci U S A 109:10310-5
(*equal contribution)

Chronic enzyme replacement therapy ameliorates neuropathology in alpha-mannosidosis mice. Damme M, Stroobants S, Lüdemann M, Rothaug M, Lüllmann-Rauch R, Beck HC, Ericsson A, Andersson C, Fogh J, D’Hooge R, Saftig P, Blanz J (2015)  Ann Clin Transl Neurol 2:987-1001

Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in α-mannosidosis. Damme M, Stroobants S, Walkley SU, Lüllmann-Rauch R, D’Hooge R, Fogh J, Saftig P, Lübke T, Blanz J (2011) J Neuropathol Exp Neurol 70:83-94

Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis. Damme M, Morelle W, Schmidt B, Andersson C, Fogh J, Michalski JC, Lübke T (2010)  Mol Cell Biol 30:273-83